Main Street Inn
Bed and breakfast, 3-star221 East Main Street, Vermillion, SD, United StatesShow on map
9.6 · Exceptional15 reviews
- Check-in from 3:00 PMCheck-out by 11:00 AM.
- Exceptional locationGuests rate the location 9.8 out of 10, at 221 East Main Street.
- Free parkingThe property states parking on site is free for guests.
City Views and Family Rooms
Enjoy stunning city views from Main Street Inn. Our spacious family rooms are perfect for a comfortable stay with your loved ones.
Modern Amenities
Experience convenience with air conditioning, flat-screen TV with streaming services, and free WiFi in every unit. Relax with a shower, hair dryer, and coffee machine provided for your comfort.
What this place offers
- WiFi available
- Free WiFi
- Parking
- Free Parking
- Non-smoking rooms
- Air conditioning
- Heating
- Family rooms
- Non-smoking throughout
- Private parking
Rooms
9.6
Exceptional
Rated 9.6 out of 10 by 15 guests who stayed here.
- Cleanliness9.5
- Service9.9
- Location9.8
- Rooms9.6
- Amenities9.2
- Value9.5
- Food & drink9.7
Guests mention
Welcoming atmosphereComfortable roomsDelicious breakfast
FCX75016FranceExcellent location in a nice little town. Large room. Quiet situation. Free snacks and beverages. Good breakfast.
The doors were noisy when opened.
AmandaUnited StatesClean, friendly, and loved the style!
The room was beautiful, and we enjoyed pulling games from the cabinet.
Nothing.
CyntheUnited StatesMuch better than staying at a chain hotel!
Location very close to the cure downtown and USD campus. Quiet. Great breakfasts. Owner is friendly and very accommodating.
Having a choice of pillow hardness would be nice. Mine were quite beefy, which I am sure is fine…
EcclestonUnited StatesQuaint, cozy and enjoyable stay in every way possible.
Everything about this place is lovely. From the owners to the staff, everyone is very accommodating and they go above and beyond to make your stafy enjoyable. The custom wood work, comfortable beds, nicely updated…
SusanUnited StatesWe Love staying at the Main Street Inn!!!
We Love staying at the Main Street Inn! It’s a beautiful, homey, Bed & Breakfast with fantastic hosts. The chef style breakfast is Fabulous!
TinaUnited StatesWould stay here again!
The staff were friendly and helpful. The room was very clean and comfortable. The history of the place was pretty neat.
You had to share a fridge with the other guests, but it wasn't horrible.
Reviews are written by guests who booked through our supplier and stayed, shown as written and in their own language. Category scores are the supplier’s reading of recent reviews, updated January 2026.
Where you’ll be
221 East Main Street, Vermillion, SD, United States
Guests rate the location 9.8 out of 10 — exceptional.
Things to know
Cancellation
Each room shows its own terms before you pay.
Most rates can be cancelled free until a date shown on the room.
Non-refundable rates are marked as such.
House rules
Check-in from 3:00 PM until 09:00 PM
Check-out by 11:00 AM
Children welcome
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No pets
Free parking on site
Non-smoking rooms available
Payment & property
Paid when you book, not at the desk.
Rates include the taxes and fees we can read.
The property may take a card at check-in for incidentals.
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Guests are required to show a photo ID and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply. A deposit may be required at the property.
What we’d check for you here
- Whether there is room for a pickup, a trailer or a van, not just a car.
- Whether breakfast is in the rate or added at checkout, and what time it runs.
- Whether the rate moves for your dates, and what it includes.
- What the property actually charges at the desk on top of the rate.
Questions about Main Street Inn
What time is check-in and check-out at Main Street Inn?
Check-in is from 3:00 PM. Check-out is by 11:00 AM. If you're arriving late, tell us and we'll ask the property to hold the room.
Does Main Street Inn allow pets?
No — the property states that pets are not allowed.
Is there parking at Main Street Inn?
Yes — the property states that parking on site is free. Whether a space can be reserved in advance varies, so we check it against your dates.
Is breakfast included at Main Street Inn?
Breakfast is offered at the property. Whether it's included depends on the rate — the board type is shown on each room once you put your dates in.
Does Main Street Inn have Wi-Fi?
Yes — internet access is listed among the property's facilities.
How do I book Main Street Inn?
Put your dates in above and book online, or call (888) 789-8585 and we'll do it for you — including things a booking form can't handle, like a block of rooms, a monthly rate or an invoice for your employer.
Where is Main Street Inn?
221 East Main Street, Vermillion, SD.
Other places we book in Vermillion
Nothing to do with the booking above. The same market, priced the same way, for if this one is not it.
